University of Chicago
The Section of Hematology/Oncology has a proud and long tradition of excellence in research-based patient care and clinical discovery. Ranked among the finest cancer programs in the country, the Section is comprised of nationally and internationally known faculty with expertise in all major types of malignancies, blood disorders, and experimental therapies.
About the Department
Dr. Caner Saygin's laboratory at the University of Chicago Comprehensive Cancer Center is seeking a highly motivated and talented Lab Manager to join our team. Our lab focuses on the investigation of leukemia evolution from pre-leukemic states (e.g., clonal hematopoiesis) and development of novel experimental therapeutics for treatment of acute leukemia. This position presents a unique opportunity to contribute to groundbreaking research aimed at improving therapeutic approaches and patient outcomes in acute leukemia.
Conduct cutting-edge research on the molecular mechanisms of leukemogenesis, including single cell multi-omics (RNA-seq, proteomics, DNA seq) analysis of primary human samples and transgenic animal models with clonal hematopoiesis and acute leukemia (AML and ALL).
Study the mechanisms driving lymphoid vs myeloid leukemogenesis from clonal hematopoiesis (in vivo models and patient samples).
Design and execute experiments utilizing cell lines, patient-derived samples, and animal models to evaluate novel therapeutic strategies.
Investigate mechanisms of treatment resistance in acute leukemia, including resistance to chemotherapy and targeted therapies.
Collaborate with multidisciplinary teams within the lab and establish collaborations with external research groups.
Analyze and interpret experimental data, prepare scientific reports, and present findings at national and international conferences.
Publish research findings in scientific journals to contribute to the scientific community’s understanding of clonal hematopoiesis and acute leukemia.
Lab management, including maintaining protocols (IACUC, IBC), ordering, assistance with creating budgets for clinical trials.
Uses subject matter and best practices knowledge to perform lab and/or research-related duties and tasks. Works independently to assist with project design.
Solves complex problems relating to the administration of projects, including planning new procedures, adapting existing procedures to the needs of the project, and making significant contributions to methodology.
Performs other related work as needed.
Education:Minimum requirements include a college or university degree in related field.
Advanced degree in Molecular Biology, Cancer Biology, Hematology or relevant field.
Experience in cell culture techniques, molecular biology techniques (PCR, cloning, Western blotting, etc.), and functional assays.
Previous lab management experience.
Strong background in cancer biology, genetics, molecular signaling pathways, and/or hematological malignancies.
Proficiency in bioinformatics and data analysis tools for high-throughput genomic data would be advantageous.
Demonstrated ability to work independently, design and execute experiments, and troubleshoot technical challenges.
Excellent verbal and written communication skills, with the ability to present research findings effectively.
Strong publication record or evidence of potential to publish in peer-reviewed scientific journals.
Cover Letter (required)
When applying, the document(s) MUST be uploaded via the My Experience page, in the section titled Application Documents of the application.
Scheduled Weekly Hours
Drug Test Required
Health Screen Required
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