University of Chicago
The position is in the Department of Medicine, Section of Rheumatology, specifically, Dr. Lin Shen’s laboratory.
About the Department
The Section of Rheumatology is a dynamic and growing enterprise of approximately forty faculty, staff, and fellows who are committed to providing outstanding state-of-the-art patient care, understanding the pathogenesis of autoimmune diseases, and training the next generation of physicians and scientists. We have well-developed basic science research programs where our primary focus is on understanding the development and regulation of lymphocytes which is fundamental to the pathogenesis of most autoimmune diseases.
These are exciting times in Rheumatology. Remarkable advances in our knowledge of basic immunology are beginning to translate into new and better treatments for those suffering from autoimmune and metabolic diseases. The Section is well poised to both take advantage and contribute to these revolutions in the understanding and treatment of rheumatic diseases.
The Section of Rheumatology is looking for a full-time Research Technician to support the day-to-day operational and research needs within the Shen Lab in the Department of Medicine.
Autoimmune rheumatic diseases, which constitute a broad range of chronic illnesses, cause significant morbidity and mortality in the US and worldwide. T cell receptor (TCR) recognition and signaling have long be recognized to play a critical role in the pathogenesis of autoimmune diseases. However, how altered TCR signaling strength affects immune tolerance and promotes autoimmunity remains incompletely understood. The major goal of Dr. Shen’s laboratory is to understand how abnormal TCR signaling resulting from mutations from human patients with complex autoimmune syndrome may alter T cell antigen sensitivity and impair immune tolerance. Studying human monogenic diseases with known genetic defects and autoimmune phenotypes provides us with a unique opportunity for advancing our knowledge of disease pathogenesis of more common polygenic autoimmune diseases.
Assists with planning, development, and execution of research in the laboratory.
Maintains experimental records.
Assists with organizing and managing the laboratory inventory.
Assists with maintaining mouse colonies, genotyping, and PCR.
Assists with maintaining cell lines, flow cytometry.
Collects and enters data. Assists with analysis of data and with preparation of reports, manuscripts and other documents.
Complies with institution, state and federal regulatory policies, procedures, directives, and mandates.
Maintains technical and administrative support for a research project.
Analyzes and maintains data and/or specimens. Conducts literature reviews. Assists with preparation of reports, manuscripts and other documents.
Performs other related work as needed.
Education:Minimum requirements include a college or university degree in related field.
Bachelor's degree in a field relevant to the research being conducted.
Relevant research experience in immunology, molecular biology and/or biochemistry.
Conducting wet lab work in a research laboratory environment.
Experience with mice handling.
Experience with flow cytometry.
Demonstrated problem-solving, organization, analytical, and coordination skills including attention to details.
Motivated to learn new skills and techniques.
Excellent verbal and written communication skills.
Ability to work independently and as part of a team.
Ability to multi-task as needed.
Mature, reliable, and professional.
Familiarity with cell culture sterile techniques.
Basic molecular biology skills.
Familiarity with common software programs such as Word, Excel, PowerPoint, and Web-based applications.
Cover Letter (required)
When applying, the document(s) MUST be uploaded via the My Experience page, in the section titled Application Documents of the application.
Scheduled Weekly Hours
Drug Test Required
Health Screen Required
Motor Vehicle Record Inquiry Required
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