University of Chicago
The Mastrianni Lab is within the Department of Neurology at the University of Chicago. The lab has been in existence for more than 20 years. The research, which has been funded by the National Institutes of Health (NIH), the Howard Hughes Medical Institute, the Alzheimer’s Association, the Brain Research Foundation, among many others, focuses on understanding animal and human prion diseases. These are progressive neurodegenerative disorders that are also transmissible. They include Creutzfeldt-Jakob disease, Gerstmann-Sträussler-Scheinker disease, fatal insomnia, and mad cow disease, among others. Prion diseases share many similarities with more common neurodegenerative conditions, such as Alzheimer’s disease, Parkinson’s disease, and Amyotrophic Lateral Sclerosis (ALS). As such, the work in studies that are aimed at understanding and correcting the underlying defect in prion diseases can help to improve the understanding of these more common diseases. In fact, recent work from the Mastrianni Lab has recognized a link between prion protein and Alzheimer’s Disease. Understanding this relationship is a current focus of study, in addition to developing gene therapy for genetic prion disease.
About the Department
The Mastrianni Lab is looking for a Staff Scientist to study the underlying pathophysiology and cell biology of neurodegenerative dementias, in particular prion disease and Alzheimer’s Disease.
The Staff Scientist is expected to plan, execute, facilitate, and advance technical/scientific research projects. He/she will design, develop, and test experimental protocols for research studies that focus on the neurodegenerative processes of dementia, including those that enhance risk, facilitate detection and prediction, in addition to therapeutic applications. The Staff Scientist will collaborate with other researchers as appropriate, participate in the preparation and writing of grant applications and reports, and co-author scientific research manuscripts. Supervision of other research staff, including postdoctoral fellows and graduate students will also be a feature of this position. Presentation of their work at scientific meetings is expected, as is a providing peer review of grant applications and scientific manuscripts.
Design, develop and test experimental protocols for research (including empirical protocols, computational, statistical methods, etc.).
Collaborate with other researchers as appropriate.
Participate in the preparation and writing of grant applications and reports, and co-author scientific research manuscripts.
Contribute to the supervision of other research staff and students.
Serves as a resource for collecting data and performing analysis. Facilitates and promotes a research project by providing scientific or intellectual information.
Develops laboratory protocols and training on new techniques. Manage, analyze and make recommendations on complex data sets for research.
Performs other related work as needed.
Education:Minimum requirements include a PhD in related field.
Doctoral degree in biological sciences or related field.
Experience in neurodegenerative disease.
A strong publication record and demonstrated commitment to excellence in research.
Experience assisting with the training of pre- and post- doctoral students.
Knowledge of cell and molecular biology methods, and analysis.
Knowledge of neuropathological assessments of mouse models of neurodegeneration and analytic methods of measure.
Knowledge of regulatory policies and procedures.
Knowledge of analytical methods and their application.
Attention to detail.
Excellent verbal and written communication skills.
Ability to work independently and as part of a team.
Cover Letter (required)
When applying, the document(s) MUST be uploaded via the My Experience page, in the section titled Application Documents of the application.
Scheduled Weekly Hours
Drug Test Required
Health Screen Required
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