Staff Scientist

University of Chicago

University of Chicago

This job is no longer accepting applications

See open jobs at University of Chicago.
Chicago, IL, USA
Posted on Saturday, December 9, 2023


BSD NEU - Mastrianni Lab

About the Department

The Mastrianni Lab is within the Department of Neurology at the University of Chicago. The lab has been in existence for more than 20 years. The research, which has been funded by the National Institutes of Health (NIH), the Howard Hughes Medical Institute, the Alzheimer’s Association, the Brain Research Foundation, among many others, focuses on understanding animal and human prion diseases. These are progressive neurodegenerative disorders that are also transmissible. They include Creutzfeldt-Jakob disease, Gerstmann-Sträussler-Scheinker disease, fatal insomnia, and mad cow disease, among others. Prion diseases share many similarities with more common neurodegenerative conditions, such as Alzheimer’s disease, Parkinson’s disease, and Amyotrophic Lateral Sclerosis (ALS). As such, the work in studies that are aimed at understanding and correcting the underlying defect in prion diseases can help to improve the understanding of these more common diseases. In fact, recent work from the Mastrianni Lab has recognized a link between prion protein and Alzheimer’s Disease. Understanding this relationship is a current focus of study, in addition to developing gene therapy for genetic prion disease.

Job Summary

The Mastrianni Lab is looking for a Staff Scientist to study the underlying pathophysiology and cell biology of neurodegenerative dementias, in particular prion disease and Alzheimer’s Disease.

The Staff Scientist is expected to plan, execute, facilitate, and advance technical/scientific research projects. He/she will design, develop, and test experimental protocols for research studies that focus on the neurodegenerative processes of dementia, including those that enhance risk, facilitate detection and prediction, in addition to therapeutic applications. The Staff Scientist will collaborate with other researchers as appropriate, participate in the preparation and writing of grant applications and reports, and co-author scientific research manuscripts. Supervision of other research staff, including postdoctoral fellows and graduate students will also be a feature of this position. Presentation of their work at scientific meetings is expected, as is a providing peer review of grant applications and scientific manuscripts.


  • Design, develop and test experimental protocols for research (including empirical protocols, computational, statistical methods, etc.).

  • Collaborate with other researchers as appropriate.

  • Participate in the preparation and writing of grant applications and reports, and co-author scientific research manuscripts.

  • Contribute to the supervision of other research staff and students.

  • Serves as a resource for collecting data and performing analysis. Facilitates and promotes a research project by providing scientific or intellectual information.

  • Develops laboratory protocols and training on new techniques. Manage, analyze and make recommendations on complex data sets for research.

  • Performs other related work as needed.

Minimum Qualifications


Minimum requirements include a PhD in related field.

Work Experience:

Minimum requirements include knowledge and skills developed through 5-7 years of work experience in a related job discipline.



Preferred Qualifications


  • Doctoral degree in biological sciences or related field.


  • Experience in neurodegenerative disease.

  • A strong publication record and demonstrated commitment to excellence in research.

  • Experience assisting with the training of pre- and post- doctoral students.

Preferred Competencies

  • Knowledge of cell and molecular biology methods, and analysis.

  • Knowledge of neuropathological assessments of mouse models of neurodegeneration and analytic methods of measure.

  • Knowledge of regulatory policies and procedures.

  • Knowledge of analytical methods and their application.

  • Problem-solving skills.

  • Attention to detail.

  • Organizational skills.

  • Excellent verbal and written communication skills.

  • Ability to work independently and as part of a team.

Application Documents

  • Resume/CV (required)

  • Cover Letter (required)

When applying, the document(s) MUST be uploaded via the My Experience page, in the section titled Application Documents of the application.

Job Family


Role Impact

Individual Contributor

FLSA Status


Pay Frequency


Scheduled Weekly Hours


Benefits Eligible


Drug Test Required


Health Screen Required


Motor Vehicle Record Inquiry Required


Posting Statement

The University of Chicago is an Affirmative Action/Equal Opportunity/Disabled/Veterans and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender, gender identity, national or ethnic origin, age, status as an individual with a disability, military or veteran status, genetic information, or other protected classes under the law. For additional information please see the University's Notice of Nondiscrimination.

Staff Job seekers in need of a reasonable accommodation to complete the application process should call 773-702-5800 or submit a request via Applicant Inquiry Form.

We seek a diverse pool of applicants who wish to join an academic community that places the highest value on rigorous inquiry and encourages a diversity of perspectives, experiences, groups of individuals, and ideas to inform and stimulate intellectual challenge, engagement, and exchange.

All offers of employment are contingent upon a background check that includes a review of conviction history. A conviction does not automatically preclude University employment. Rather, the University considers conviction information on a case-by-case basis and assesses the nature of the offense, the circumstances surrounding it, the proximity in time of the conviction, and its relevance to the position.

The University of Chicago's Annual Security & Fire Safety Report (Report) provides information about University offices and programs that provide safety support, crime and fire statistics, emergency response and communications plans, and other policies and information. The Report can be accessed online at: http://securityreport.uchicago.edu. Paper copies of the Report are available, upon request, from the University of Chicago Police Department, 850 E. 61st Street, Chicago, IL 60637.

This job is no longer accepting applications

See open jobs at University of Chicago.